A new fatty alcohol 1-icos-17-en-1-ol (1), 1-octacosanol (2), 1-triacontanol (3), Umbelliferone (4) and skimmin (5), were isolated from the aerial parts of Phellolophium madagascariensis (Apiaceae), an endemic species of Madagascar. Structure elucidations of the compounds were performed by using spectroscopic methods (1-D and 2-D NMR, EI-MS) and comparison with literature data. To the best of our knowledge, all of the compounds have been isolated for the first time from Phellolophium madagascariensis.